| Most 100 Yard Rushing Games | Games | |
|---|---|---|
| 1 |  James Cook, BUF | 9 |
| 2 | Derrick Henry, BAL | 8 |
| 3 | Jonathan Taylor, IND | 5 |
| 4 | Bijan Robinson, ATL | 5 |
| 5 | Breece Hall, NYJ | 4 |
| 6 | De'Von Achane, MIA | 4 |
| 7 | Christian McCaffrey, SFO | 4 |
| 8 | D'Andre Swift, CHI | 3 |
| 9 | Chase Brown, CIN | 3 |
| 10 | Saquon Barkley, PHI | 3 |
| More Leaders | ||
| Best Rushing Average | Avg Yards | |
|---|---|---|
| 1 | James Cook, BUF | 95.35 |
| 2 | Derrick Henry, BAL | 93.82 |
| 3 | Jonathan Taylor, IND | 93.24 |
| 4 | Bijan Robinson, ATL | 86.94 |
| 5 | De'Von Achane, MIA | 84.38 |
| 6 | J.K. Dobbins, DEN | 77.20 |
| 7 | Javonte Williams, DAL | 75.06 |
| 8 | Kyren Williams, LAR | 73.65 |
| 9 | Jahmyr Gibbs, DET | 71.94 |
| 10 | Saquon Barkley, PHI | 71.25 |
| More Leaders | ||
| Best Single Game Total | Game | Yards | |
|---|---|---|---|
| 1 | Jonathan Taylor | Week 10: ATL @ IND | 244 |
| 2 | Jahmyr Gibbs | Week 12: NYG @ DET | 219 |
| 3 | James Cook | Week 8: BUF @ CAR | 216 |
| 4 | Derrick Henry | Week 17: BAL @ GNB | 216 |
| 5 | Rico Dowdle | Week 5: MIA @ CAR | 206 |
| 6 | Bijan Robinson | Week 17: LAR @ ATL | 195 |
| 7 | Rico Dowdle | Week 6: DAL @ CAR | 183 |
| 8 | Kyle Monangai | Week 9: CHI @ CIN | 176 |
| 9 | De'Von Achane | Week 10: BUF @ MIA | 174 |
| 10 | Bijan Robinson | Week 6: BUF @ ATL | 170 |
| More Leaders | |||
| Total Yards this Season | Yards | |
|---|---|---|
| 1 | James Cook, BUF | 1621 |
| 2 | Derrick Henry, BAL | 1595 |
| 3 | Jonathan Taylor, IND | 1585 |
| 4 | Bijan Robinson, ATL | 1478 |
| 5 | De'Von Achane, MIA | 1350 |
| 6 | Kyren Williams, LAR | 1252 |
| 7 | Jahmyr Gibbs, DET | 1223 |
| 8 | Christian McCaffrey, SFO | 1202 |
| 9 | Javonte Williams, DAL | 1201 |
| 10 | Saquon Barkley, PHI | 1140 |
| More Leaders | ||